https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24018 Wed 24 Nov 2021 15:51:27 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36437 Wed 23 Feb 2022 16:02:31 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36903 Wed 17 Nov 2021 16:30:02 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30306 Wed 15 Dec 2021 16:09:28 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:6849 Wed 11 Apr 2018 16:39:01 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26763 Wed 11 Apr 2018 15:09:54 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19104 Wed 11 Apr 2018 13:29:44 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:6851 Wed 11 Apr 2018 10:50:17 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:4378 A, causes overexpression and supports uncontrollable cellular growth. This polymorphism has been associated with an increased risk of developing many cancers, including endometrial cancer. Methods: The 870 G>A polymorphisms (rs605965) in the cyclin D1 gene was genotyped in an Australian endometrial cancer case-control population including 191 cases and 291 controls using real-time PCR analysis. Genotype analysis was performed using chi-squared (χ²) statistics and odds ratios were calculated using unconditional logistic regression, adjusting for potential endometrial cancer risk factors. Results: Women homozygous for the variant cyclin D1 870 AA genotype showed a trend for an increased risk of developing endometrial cancer compared to those with the wild-type GG genotype, however this result was not statistically significant (OR 1.692 95% CI (0.939-3.049), p = 0.080). Moreover, the 870 G>A polymorphism was significantly associated with family history of colorectal cancer. Endometrial cancer patients with the homozygous variant AA genotype had a higher frequency of family members with colorectal cancer in comparison to endometrial cancer patients with the GG and combination of GG and GA genotypes (GG versus AA; OR 2.951, 95% CI (1.026-8.491), p = 0.045, and GG+GA versus AA; OR 2.265, 95% CI (1.048-4.894), p = 0.038, respectively). Conclusion: These results suggest that the cyclin D1 870 G>A polymorphism is possibly involved in the development of endometrial cancer. A more complex relationship was observed between this polymorphism and familial colorectal cancer.]]> Wed 11 Apr 2018 10:44:26 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9714 Wed 11 Apr 2018 09:43:06 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20605 Wed 09 Sep 2015 15:19:23 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30018 Tue 20 Sep 2022 14:49:52 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54240 Tue 13 Feb 2024 13:19:59 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39121 Tue 10 May 2022 17:21:35 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34895 Tue 03 Sep 2019 18:23:20 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26776 Thu 11 Apr 2019 13:18:13 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50482 Sun 06 Aug 2023 10:16:27 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7929 Sat 24 Mar 2018 08:41:42 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9354 Sat 24 Mar 2018 08:36:33 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10397 Sat 24 Mar 2018 08:08:45 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17481 Sat 24 Mar 2018 08:04:10 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:4766 Sat 24 Mar 2018 07:20:43 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42628 Mon 19 Jun 2023 14:35:48 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46175 Mon 14 Nov 2022 15:50:19 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26801 Fri 10 Mar 2023 19:17:25 AEDT ]]>